5-iodo-7-oxetan-3-yl-7H-pyrrolo[2,3-d]pyrimidine → {5-[(Diphenylmethylene)amino]pyridin-3-yl}(7-oxetan-3-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

HRID 82179Notes

Reaction equation

HRID 82179 reaction equation
I[C:2]1[C:10]2[CH:9]=[N:8][CH:7]=[N:6][C:5]=2[N:4]([CH:11]2[CH2:14][O:13][CH2:12]2)[CH:3]=1.[C:15]1([C:21](=[N:28][C:29]2[CH:30]=[N:31][CH:32]=[C:33]([CH:40]=2)[C:34](N(OC)C)=[O:35])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([C:21](=[N:28][C:29]2[CH:40]=[C:33]([C:34]([C:2]3[C:10]4[CH:9]=[N:8][CH:7]=[N:6][C:5]=4[N:4]([CH:11]4[CH2:14][O:13][CH2:12]4)[CH:3]=3)=[O:35])[CH:32]=[N:31][CH:30]=2)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 708176335-iodo-7-oxetan-3-yl-7H-pyrrolo[2,3-d]pyrimidineHCID 866720805-((Diphenylmethylene)amino)-N-methoxy-N-methylnicotinamide

Product 1

HCID 86672099{5-[(Diphenylmethylene)amino]pyridin-3-yl}(7-oxetan-3-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

Procedure

The title compound was prepared according to the method described for Preparation 94 using 5-iodo-7-oxetan-3-yl-7H-pyrrolo[2,3-d]pyrimidine (Preparation 98) and 5-[(diphenylmethylene)amino]-N-methoxy-N-methylnicotinamide (Preparation 23) to afford the title compound as a yellow solid in 55% yield, 253 mg.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9790aa1f53af410e983cc012efa9b9fa
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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