5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide → (5-Bromopyridin-3-yl)(2-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

HRID 82187Notes

Reaction equation

HRID 82187 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10](I)=[CH:9][N:8]([CH:12]([CH3:14])[CH3:13])[C:6]=2[N:7]=1.[Br:15][C:16]1[CH:17]=[N:18][CH:19]=[C:20]([CH:27]=1)[C:21](N(OC)C)=[O:22]>>[Br:15][C:16]1[CH:27]=[C:20]([C:21]([C:10]2[C:5]3[CH:4]=[N:3][C:2]([Cl:1])=[N:7][C:6]=3[N:8]([CH:12]([CH3:14])[CH3:13])[CH:9]=2)=[O:22])[CH:19]=[N:18][CH:17]=1

Participants

3

Reactant 2

HCID 184722695-Bromo-N-methoxy-N-methylpyridine-3-carboxamideHCID 866721052-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 86672104(5-Bromopyridin-3-yl)(2-chloro-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

Procedure

The title compound was prepared according to the method described for Preparation 28 using 2-chloro-5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine (Preparation 120) and 5-bromo-N-methoxy-N-methylnicotinamide to afford the title compound as a yellow solid in 41% yield, 1.2 g.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-9557cf69593f480c955f0d78770bf0b4
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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