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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 82198Generated: October 25, 2026

3-(Trifluoromethyl)benzeneacetic acid → N-(5-{[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)-2-[3-(trifluoromethyl)phenyl]acetamide

https://huagongshe.com/reaction/82198

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzeneacetic acidHCID 67695—
ReactantDiisopropylethylamineHCID 81531—
Reactant(5-aminopyridin-3-yl)[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanoneHCID 70817221—
ProductN-(5-{[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl}pyridin-3-yl)-2-[3-(trifluoromethyl)phenyl]acetamideHCID 70817589—

Reaction Steps

Prepared according to the method described for Example 1 using (5-aminopyridin-3-yl)[7-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]methanone (Preparation 38), and 3-trifluoromethylphenylacetic acid with DIPEA.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846698B2
Source datasetuspto-grants-2014_09
ORD IDord-30d1f3cf3dc14025b3cee543dfaf84de
Source noteuspto-grants-2014_09