Diisopropylethylamine → N-[5-({7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	2-(4-Isopropyl-1H-1,2,3-triazol-1-yl)acetic acid	HCID 18524442	—
Reactant	(5-Aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone	HCID 70817116	—
Product	N-[5-({7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}carbonyl)pyridin-3-yl]-2-(4-isopropyl-1H-1,2,3-triazol-1-yl)acetamide	HCID 70817659	—

Reaction Steps

Prepared according to the method described above for Example 1, using (5-aminopyridin-3-yl){7-[(1R)-1-methyl-2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}methanone (Preparation 36) and (4-isopropyl-1H-1,2,3-triazol-1-yl)acetic acid with DIPEA as base.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846698B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-b350cd516d3b485d87c891859cd0e254
Source note	uspto-grants-2014_09