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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 822277Generated: October 26, 2026

Water → 4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamide

https://huagongshe.com/reaction/822277

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantIsopropanolHCID 3776—
Reactant2-Methylbenzenesulfonic acidHCID 6925—
Reactant2-Chloro-9-cyclohexyl-7,7-difluoro-5-methyl-5,7,8,9-tetrahydro-pyrimido[4,5-b][1,4]diazepin-6-oneHCID 57955554—
Reactant4-amino-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamideHCID 58015118—
Product4-(9-cyclohexyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-[1-(2,2-difluoro-ethyl)-piperidin-4-yl]-3-methoxy-benzamideHCID 58015055—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-cc611135d05546ceb69dd4d431ce62cb
Source noteTest data from https://doi.org/10.1039/C8SC04228D