6-chloro-N-(4-methoxyphenyl)nicotinamide → 6-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(4-methoxyphenyl)nicotinamide

HRID 822289Notes

Reaction equation

HRID 822289 reaction equation
[CH:19]1([NH:22][C:23]([c:24]2[cH:25][c:26]([B:31]3[O:32][C:33]([CH3:34])([CH3:35])[C:36]([CH3:37])([CH3:38])[O:39]3)[c:27]([CH3:30])[cH:28][cH:29]2)=[O:40])[CH2:20][CH2:21]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][cH:11][c:12]([O:15][CH3:16])[cH:13][cH:14]2)[cH:17][cH:18]1>>[c:2]1(-[c:26]2[cH:25][c:24]([C:23]([NH:22][CH:19]3[CH2:20][CH2:21]3)=[O:40])[cH:29][cH:28][c:27]2[CH3:30])[n:3][cH:4][c:5]([C:6](=[O:7])[NH:8][c:9]2[cH:10][cH:11][c:12]([O:15][CH3:16])[cH:13][cH:14]2)[cH:17][cH:18]1

Participants

3

Reactant 2

HCID 14832696-chloro-N-(4-methoxyphenyl)nicotinamideHCID 21914577N-cyclopropyl-4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

Product 1

HCID 219145916-[5-Cyclopropylcarbamoyl-2-methyl-phenyl]-N-(4-methoxyphenyl)nicotinamide

Sources & evidence

ORD record
ord-61afbfb2e076434394ff9ad68416011d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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