Tert-butyl 1H-pyrazolo[4,3-b]pyridin-1-ylacetate → 1H-Pyrazolo[4,3-b]pyridin-1-ylacetic acid

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Reaction Steps

Tert-butyl 1H-pyrazolo[4,3,b]pyridin-1-ylacetate (Preparation 189, 220 mg, 0.944 mmol) was dissolved in HCl (4 mL, 4.0 M in 1,4 dioxane) and stirred under nitrogen at room temperature for 4 hours. The mixture was evaporated in vacuo and the residue was triturated with anhydrous diethyl ether to afford the title compound as an off white solid in 60% yield, 120 mg.

Provenance & Evidence