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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 822418Generated: October 31, 2026

1,2-Dichloroethane → rac-(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-4-fluoro-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amide

https://huagongshe.com/reaction/822418

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-AminobenzonitrileHCID 13396—
ReactantDiphenylphosphinic chlorideHCID 73910—
ReactantDiisopropylethylamineHCID 81531—
ReactantHCID 76741111HCID 76741111—
Productrac-(2'S,3'R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-4-fluoro-2-oxo-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid (4-cyano-phenyl)-amideHCID 75986161—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-5cbe5c6512374dc5a4e718eb4bfd0cc2
Source noteTest data from https://doi.org/10.1039/C8SC04228D