HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-2-methyl-1,3-propanediol → 2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-methylpropane-1,3-diol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-2-methyl-1,3-propanediol | HCID 1531 | — |
| Reactant | (4,6-Dichloropyrimidin-5-yl)acetaldehyde | HCID 13989292 | — |
| Product | 2-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-methylpropane-1,3-diol | HCID 86672117 | — |
Reaction Steps
The title compound was prepared according to the method described for Preparation 1 using (4,6-dichloropyrimidin-5-yl)acetaldehyde (Preparation 208) and 2-amino-2-methylpropane-1,3-diol to afford the title compound as a yellow liquid in 79% yield, 3.88 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846698B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8fc5262635fb42f4819494c895016789 |
| Source note | uspto-grants-2014_09 |