Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

(5,8-Dihydro-6H-[1,7]naphthyridin-7-yl)-acetic acid tert-butyl ester (Preparation 234, 1.25 g, 5.03 mmol) was treated with 4N HCl in dioxane (25 ml) at room temperature for 2 hours. The mixture was evaporated to dryness in vacuo and the solid residue was triturated with diethyl ether to afford the title compound as white solid in 78% yield (calculated as HCl salt), 900 mg.

Provenance & Evidence