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Ether, ethyl ethynyl → [2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ether, ethyl ethynyl | HCID 61239 | — |
| 反応物 | Benzcatechinborane | HCID 6327445 | — |
| 反応物 | (5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine | HCID 86672124 | — |
| 生成物 | [2-Chloro-5-((E)-2-ethoxy-vinyl)-pyrimidin-4-yl]-(2-methoxy-1,1-dimethyl-ethyl)-amine | HCID 86672125 | — |
反応手順
The title compound was prepared according to the method described for Preparation 61 using (5-Bromo-2-chloro-pyrimidin-4-yl)-(2-methoxy-1,1-dimethyl-ethyl)-amine (Preparation 256), catechol borane and ethoxyacetylene (40% in hexane) to afford the title compound as light brown gum in 44% yield, 2.6 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08846698B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-1ce22986ba4a440495b30bf3ade47f58 |
| 出典メモ | uspto-grants-2014_09 |