5-Bromo-N-methoxy-N-methylpyridine-3-carboxamide → HCID 70817189, compound

HRID 82284Notes

Reaction equation

HRID 82284 reaction equation
I[C:2]1[C:10]2[CH:9]=[N:8][CH:7]=[N:6][C:5]=2[N:4]([C:11]([CH3:16])([CH3:15])[CH2:12][O:13][CH3:14])[CH:3]=1.[Br:17][C:18]1[CH:19]=[N:20][CH:21]=[C:22]([CH:29]=1)[C:23](N(OC)C)=[O:24]>>[Br:17][C:18]1[CH:29]=[C:22]([C:23]([C:2]2[C:10]3[CH:9]=[N:8][CH:7]=[N:6][C:5]=3[N:4]([C:11]([CH3:16])([CH3:15])[CH2:12][O:13][CH3:14])[CH:3]=2)=[O:24])[CH:21]=[N:20][CH:19]=1

Participants

3

Reactant 2

HCID 184722695-Bromo-N-methoxy-N-methylpyridine-3-carboxamideHCID 70817500HCID 70817500, compound

Product 1

HCID 70817189HCID 70817189, compound

Procedure

The title compound was prepared according to the method described for Preparation 64 using 5-Iodo-7-(2-methoxy-1,1-dimethyl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine (Preparation 262) and 5-Bromo-N-methoxy-N-methyl-nicotinamide to afford the title compound as light brown gum in 51% yield, 3 g.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-c4b8f0115ce745628a8d60b3993ed75f
Source dataset
uspto-grants-2014_09
Patent number
US08846698B2

Reaction notes

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