反应详情

To a stirred solution of (4-nitro-phenyl)-acetic acid (3 g, 16.4 mmol) in ethanol (30 mL) was added sulphuric acid (1 mL) and the reaction mixture was heated to reflux for 16 hours. The reaction mixture was neutralized with 2N aq. NaOH solution and extracted with EtOAc (3×50 mL). The combined organic layers were dried (Na2SO4) and evaporated in vacuo to afford the title compound as a light yellow oil in 98% yield, 3.4 g.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 16 hours
3. extractionextracted with EtOAc (3×50 mL)
4. dry with materialThe combined organic layers were dried (Na2SO4)
5. customevaporated in vacuo