反应详情

A solution of 1-pyridin-2-yl-2-quinolin-4-yl-ethanone, (0.25 g, 1 mmol) and pyridine (0.242 mL, 3 mmol) in acetic acid (2 mL) is added to 1-amino-4-(3-methoxy-phenyl)-pyrrolidin-2-one, (0.2 g, 1 mmol) at room temperature under nitrogen. The mixture is stirred 18 h and concentrated in vacuo. The residue is chromatographed on SiO2 (2% methanol/dichloromethane) to yield the title compound, 0.25 g (57%), as a yellow foam.

1. concentrationconcentrated in vacuo
2. customThe residue is chromatographed on SiO2 (2% methanol/dichloromethane)