反应详情

To a stirred solution of (4-methylamino-phenyl)-acetic acid ethyl ester (Preparation 269, 418 mg, 2.16 mmol) in pyridine (4 mL) was added methanesulfonyl chloride (0.25 mL, 3.24 mmol) and the mixture stirred at room temperature for 3 hours. The reaction mixture was quenched with water (10 mL) and extracted with EtOAc (3×15 mL). The combined organic layers were washed with water (10 mL), brine (10 mL), dried (Na2SO4) and evaporated in vacuo to afford the title compound as a gum in 78% yield, 460 mg.

1. customThe reaction mixture was quenched with water (10 mL)
2. extractionextracted with EtOAc (3×15 mL)
3. washThe combined organic layers were washed with water (10 mL), brine (10 mL)
4. dry with materialdried (Na2SO4)
5. customevaporated in vacuo