2-(Bromomethyl)-5-(trifluoromethyl)furan → 1'-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

HRID 822990Notes

Reaction equation

HRID 822990 reaction equation
[Br:63][CH2:64][c:65]1[o:66][c:67]([C:68]([F:69])([F:70])[F:71])[cH:72][cH:73]1.[CH3:22][c:23]1[c:24]2[cH:25][c:26]3[c:39]([cH:40][c:41]2[o:42][n:43]1)[O:38][CH2:37][C:27]31[c:28]2[c:29]([cH:30][cH:31][cH:32][cH:33]2)[NH:34][C:35]1=[O:36].[CH3:44][c:45]1[cH:46][cH:47][c:48]([S:49]([O:50][CH2:55][CH2:56][N:57]2[C:58](=[O:62])[O:59][CH2:60][CH2:61]2)(=[O:51])=[O:52])[cH:53][cH:54]1.[NH:1]1[C:2](=[O:21])[C:3]2([c:4]3[c:5]([cH:8][c:9]4[c:13]([cH:14]3)[CH2:12][CH2:11][O:10]4)[O:6][CH2:7]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21>>[N:1]1([CH2:55][CH2:56][N:57]2[C:58](=[O:62])[O:59][CH2:60][CH2:61]2)[C:2](=[O:21])[C:3]2([c:4]3[c:5]([cH:8][c:9]4[c:13]([cH:14]3)[CH2:12][CH2:11][O:10]4)[O:6][CH2:7]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21

Participants

5

Reactant 4

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 157609472-(2-Oxooxazolidin-3-yl)ethyl 4-methylbenzenesulfonateHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-oneHCID 593524533-methylspiro[furo[3,2-f][1,2]benzisoxazole-5,3'-indol]-2'(1H)-one

Product 1

HCID 593524071'-[2-(2-oxo-1,3-oxazolidin-3-yl)ethyl]-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-d98596e46eb243119a49316f48c8116d
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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