反应详情

Ethyl[4-(3-Hydroxyphenyl)-1H-1,2,3-triazol-1-yl]acetate (Preparation 291, 27.2 g, 0.110 mol) was dissolved in methanol (200 mL), and a solution of NaOH (4.84 g, 121 mmol) in water (40 mL) was added. The solution was kept at room temperature for 24 hours. Methanol was evaporated in vacuo, water (120 mL) was added, and the solution was refluxed with activated charcoal. The mixture was filtered, and 11 M HCl was added to the filtrate. The mixture was dissolved by addition of water (120 mL) and cooled to carry out the crystallization. The crystals were filtered, washed with water (2×25 mL), and evaporated to dryness to afford the title compound as brown crystals (mp 186.3-188.7° C.) in 99.0% yield 23.9 g. MS m/z 218 [M−H]−

1. customMethanol was evaporated in vacuo, water (120 mL)
2. additionwas added
3. temperaturethe solution was refluxed with activated charcoal
4. filtrationThe mixture was filtered
5. addition11 M HCl was added to the filtrate
6. dissolutionThe mixture was dissolved by addition of water (120 mL)
7. temperaturecooled
8. customthe crystallization
9. filtrationThe crystals were filtered
10. washwashed with water (2×25 mL)
11. customevaporated to dryness