Bicarbonate Ion → 2,4-Bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine

HRID 823377Notes

Reaction equation

HRID 823377 reaction equation
[Br:1][c:2]1[n:3][c:4]([CH3:7])[s:5][cH:6]1.[CH3:26][O:27][CH2:28][CH2:29][O:30][CH3:31].[CH3:8][O:9][c:10]1[n:11][cH:12][c:13]([B:18]([OH:19])[OH:20])[c:14]([O:16][CH3:17])[n:15]1.[Cl:32][CH2:33][Cl:34].[Na+:25].[O-:21][C:22]([OH:23])=[O:24]>>[c:2]1(-[c:13]2[cH:12][n:11][c:10]([O:9][CH3:8])[n:15][c:14]2[O:16][CH3:17])[n:3][c:4]([CH3:7])[s:5][cH:6]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 80711,2-DimethoxyethaneHCID 2736209(2,4-Dimethoxypyrimidin-5-yl)boronic acidHCID 27631864-Bromo-2-methyl-1,3-thiazole

Product 1

HCID 594483562,4-Bis(methyloxy)-5-(2-methyl-1,3-thiazol-4-yl)pyrimidine

Sources & evidence

ORD record
ord-0d96a101b8e348b7a2899b5cf908c2a5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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