反应详情

温度

60 °C

1-(2,2-difluoro-1,3-benzodioxol-5-yl)-cyclopropanecarboxylic acid (1.2 eq) is slurried in toluene (2.5 vol) and the mixture heated to 60° C. SOCl2 (1.4 eq) is added via addition funnel. The toluene and SOCl2 are distilled from the reaction mixture after 30 minutes. Additional toluene (2.5 vol) is added and distilled again.

1. distillationThe toluene and SOCl2 are distilled from the reaction mixture after 30 minutes
2. additionAdditional toluene (2.5 vol) is added
3. distillationdistilled again