Thionyl Chloride → 2-(4-Fluorobenzyl)-10-methoxy-4-(1-chloroethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

HRID 823391Notes

Reaction equation

HRID 823391 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH:25]([CH3:26])[OH:27])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([O:23][CH3:24])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:28][cH:29]1.[S:30]([Cl:31])([Cl:32])=[O:33]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[n:8][c:9]([CH:25]([CH3:26])[Cl:32])[c:10]3[c:11]([c:12]2=[O:13])[c:14]([O:23][CH3:24])[c:15]2[n:16]3[CH2:17][CH2:18][N:19]([CH3:22])[C:20]2=[O:21])[cH:28][cH:29]1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 688652402-(4-Fluorobenzyl)-10-methoxy-4-(1-hydroxyethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Product 1

HCID 688663392-(4-Fluorobenzyl)-10-methoxy-4-(1-chloroethyl)-8-methyl-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

Sources & evidence

ORD record
ord-01011cff21e744b2bcce98beb1b77ea4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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