Pyridine → 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(4-(6-methoxypyridin-3-yl)-5-methylpyrimidin-2-yl)cyclopropanecarboxamide

HRID 823765Notes

Reaction equation

HRID 823765 reaction equation
[CH3:18][O:19][c:20]1[cH:21][cH:22][c:23](-[c:26]2[n:27][c:28]([NH2:33])[n:29][cH:30][c:31]2[CH3:32])[cH:24][n:25]1.[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[Cl:16])[CH2:12][CH2:13]3)[cH:10]2)[O:6]1.[cH:34]1[cH:35][cH:36][n:37][cH:38][cH:39]1>>[F:1][C:2]1([F:17])[O:3][c:4]2[c:5]([cH:7][cH:8][c:9]([C:11]3([C:14](=[O:15])[NH:33][c:28]4[n:27][c:26](-[c:23]5[cH:22][cH:21][c:20]([O:19][CH3:18])[n:25][cH:24]5)[c:31]([CH3:32])[cH:30][n:29]4)[CH2:12][CH2:13]3)[cH:10]2)[O:6]1

Participants

4

Reactant 3

HCID 1049PyridineHCID 575168501-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl chlorideHCID 578561844-(6-Methoxypyridin-3-yl)-5-methylpyrimidin-2-amine

Product 1

HCID 578561031-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(4-(6-methoxypyridin-3-yl)-5-methylpyrimidin-2-yl)cyclopropanecarboxamide

Sources & evidence

ORD record
ord-fcd90ffa6a5240faac0461bf82ae7c95
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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