反应详情

To a solution of (R)-tert-butyl 4-(7,7-difluoro-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (0.092 g, 0.260 mmol) in 2 mL dioxane was added 4M HCl/dioxane (2.27 ml, 9.09 mmol). The reaction mixture was stirred at room temperature 16 hours, after which it was concentrated to dryness and dried in vacuo to give (R)-7,7-difluoro-5-methyl-4-(piperazin-1-yl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine dihydrochloride (0.079 g, 93.0% yield) as a pale yellow powder. MS (APCI+) m/z 255 [M+H]+.

1. concentrationafter which it was concentrated to dryness
2. customdried in vacuo