反应详情

To a solution of (1-pyridin-2-yl-2-quinolin-4-yl-ethylidene)-hydrazine (2.0 g, 7.6 mmol) in pyridine (20 mL) at 0° C. is added ethyl chloroformate (2 mL) dropwise. The mixture is warmed to room temperature and stirred for 2 h. The solution is refluxed for 12 h and concentrated in vacuo. The residue is treated with dichloromethane/methanol and the precipitate collected by vacuum filtration. The precipitate is triturated with ethanol to yield the title compound, 300 mg (13%), as a white solid.

1. temperatureThe solution is refluxed for 12 h
2. concentrationconcentrated in vacuo
3. additionThe residue is treated with dichloromethane/methanol
4. filtrationthe precipitate collected by vacuum filtration
5. customThe precipitate is triturated with ethanol