6-Bromopyridine-3-carbonitrile → 6-[4-[1-[6-(3-Hydroxypropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl]ethyl]phenyl]pyridine-3-carbonitrile

HRID 824011Notes

Reaction equation

HRID 824011 reaction equation
[Br:35][c:36]1[n:37][cH:38][c:39]([C:42]#[N:43])[cH:40][cH:41]1.[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:6][CH2:7][N:8]([CH:12]([CH3:13])[c:14]2[cH:15][cH:16][c:17]([B:20]3[O:21][C:22]([CH3:23])([CH3:24])[C:25]([CH3:26])([CH3:27])[O:28]3)[cH:18][cH:19]2)[C:9](=[O:11])[O:10]1>>[OH:1][CH2:2][CH2:3][CH2:4][C:5]1([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[CH2:6][CH2:7][N:8]([CH:12]([CH3:13])[c:14]2[cH:15][cH:16][c:17](-[c:36]3[n:37][cH:38][c:39]([C:42]#[N:43])[cH:40][cH:41]3)[cH:18][cH:19]2)[C:9](=[O:11])[O:10]1

Participants

3

Reactant 2

HCID 50057186-Bromopyridine-3-carbonitrileHCID 723443116-(3-Hydroxypropyl)-6-phenyl-3-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]ethyl]-1,3-oxazinan-2-one

Product 1

HCID 907040636-[4-[1-[6-(3-Hydroxypropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl]ethyl]phenyl]pyridine-3-carbonitrile

Sources & evidence

ORD record
ord-4e63e62ceaeb4a25b6a5b6ca3e4fb218
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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