Acetate → 6-[4-Methoxybenzyl-(6-morpholinopyridin-3-yl)amino]-4-[(trifluoroacetyl)amino]pyridine-3-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([Cl:19])[cH:10][c:11]1[NH:12][C:13]([C:14]([F:15])([F:16])[F:17])=[O:18].[CH3:20][O:21][c:22]1[cH:23][cH:24][c:25]([CH2:26][NH:27][c:28]2[cH:29][n:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[cH:32][cH:33]2)[cH:40][cH:41]1.[CH3:94][c:95]1[cH:96][cH:97][cH:98][cH:99][cH:100]1.[Na+:88].[Na+:89].[O-:102][C:103]([CH3:104])=[O:105].[O-:106][C:107]([CH3:108])=[O:109].[O-:90][C:91](=[O:92])[O-:93].[OH2:110].[Pd+2:101].[c:42]1([P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[c:50]2[cH:51][cH:52][c:53]3[c:54]([cH:55][cH:56][cH:57][cH:58]3)[c:59]2-[c:60]2[c:61]3[c:62]([cH:63][cH:64][cH:65][cH:66]3)[cH:67][cH:68][c:69]2[P:70]([c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[c:77]2[cH:78][cH:79][cH:80][cH:81][cH:82]2)[cH:83][cH:84][cH:85][cH:86][cH:87]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][c:9]([N:27]([CH2:26][c:25]2[cH:24][cH:23][c:22]([O:21][CH3:20])[cH:41][cH:40]2)[c:28]2[cH:29][n:30][c:31]([N:34]3[CH2:35][CH2:36][O:37][CH2:38][CH2:39]3)[cH:32][cH:33]2)[cH:10][c:11]1[NH:12][C:13]([C:14]([F:15])([F:16])[F:17])=[O:18]Participants
10
Reactant 9
HCID 175Acetate2×
HCID 923Sodium ion2×
HCID 962Water
HCID 1140Toluene
HCID 19660Carbonate Ion
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 634876Binap, (A+-)-
HCID 674131333-(4-Methoxybenzyl)amino-6-morpholinopyridine
HCID 866579426-Chloro-4-(trifluoroacetyl)aminopyridine-3-carboxylic acid ethyl esterProduct 1
Sources & evidence
- ORD record
- ord-94f1345c11f94eedb63a7ec1e4378945
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…