Methanol → Tert-butyl 4-hydroxypiperidine-1-carboxylate

HRID 824311Notes

Reaction equation

[BH4-:1].[CH3:17][OH:18].[Na+:2].[O:3]=[C:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1>>[OH:3][CH:4]1[CH2:5][CH2:6][N:7]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:8][CH2:9]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium ion

HCID 28123Borohydride

HCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Sources & evidence

ORD record: ord-ffde5f0cf1c0473a918ebf2eafff1132
Source dataset: Test data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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