2-oxaspiro[4.4]nonane-1,3-dione → 1-[2-(4-{4-[(4,5-Dichloro-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2-oxo-ethyl]-cyclopentanecarboxylic acid

HRID 824365Notes

Reaction equation

HRID 824365 reaction equation
[C:67]1(=[O:77])[O:68][C:69](=[O:76])[CH2:70][C:71]12[CH2:72][CH2:73][CH2:74][CH2:75]2.[CH2:1]([O:2][c:3]1[cH:4][cH:5][cH:6][c:7]2[c:8]1[cH:9][c:10]([C:11]([NH:12][c:13]1[cH:14][cH:15][c:16]([CH:17]3[CH2:18][CH2:19][N:20]([C:21](=[O:22])[CH2:23][C:24]([CH3:25])([CH3:26])[C:27]([OH:28])=[O:29])[CH2:30][CH2:31]3)[cH:32][cH:33]1)=[O:34])[n:35]2[CH2:36][CH3:37])[CH3:38].[NH:39]1[CH2:40][CH2:41][CH:42]([c:45]2[cH:46][cH:47][c:48]([NH:51][C:52](=[O:53])[c:54]3[n:55]([CH2:65][CH3:66])[c:56]4[cH:57][cH:58][c:59]([Cl:64])[c:60]([Cl:63])[c:61]4[cH:62]3)[cH:49][cH:50]2)[CH2:43][CH2:44]1>>[N:39]1([C:69]([CH2:70][C:71]2([C:67](=[O:68])[OH:77])[CH2:72][CH2:73][CH2:74][CH2:75]2)=[O:76])[CH2:40][CH2:41][CH:42]([c:45]2[cH:46][cH:47][c:48]([NH:51][C:52](=[O:53])[c:54]3[n:55]([CH2:65][CH3:66])[c:56]4[cH:57][cH:58][c:59]([Cl:64])[c:60]([Cl:63])[c:61]4[cH:62]3)[cH:49][cH:50]2)[CH2:43][CH2:44]1

Participants

4

Reactant 3

HCID 27371022-oxaspiro[4.4]nonane-1,3-dioneHCID 593651354-(4-{4-[(4-ethoxy-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2,2-dimethyl-4-oxo-butyric acidHCID 667726954,5-dichloro-1-ethyl-1H-indole-2-carboxylic acid (4-piperidin-4-yl-phenyl)-amide

Product 1

HCID 593651611-[2-(4-{4-[(4,5-Dichloro-1-ethyl-1H-indole-2-carbonyl)-amino]-phenyl}-piperidin-1-yl)-2-oxo-ethyl]-cyclopentanecarboxylic acid

Sources & evidence

ORD record
ord-a2c018011ff545b5aa6dabc940dc63e7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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