反应详情

To a mixture of sodium acetate (0.84 g, 10.2 mmol) and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II):CH2Cl2 (42 mg, 0.05 mmol) in methanol (40 mL) is added 6-bromo-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinoline (1.0 g, 2.56 mmol). The mixture is heated at 90° C. under 68 psi carbon monoxide for 24 h. The mixture is cooled, filtered, and concentrated in vacuo. The product is partitioned between ethyl acetate and: water. The organic layer is dried over sodium sulfate and concentrated in vacuo. The residue is chromatographed on SiO2 (dichloromethane to 2% methanol/dichloromethane) to yield a solid, 918 mg (97%).

1. temperatureThe mixture is cooled
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. customThe product is partitioned between ethyl acetate
5. dry with materialThe organic layer is dried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe residue is chromatographed on SiO2 (dichloromethane to 2% methanol/dichloromethane)
8. customto yield a solid, 918 mg (97%)