Hydroxide → 4-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]aminomethyl]piperidine

HRID 825349Notes

Reaction equation

HRID 825349 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][N:7]2[CH2:8][CH2:9][CH:10]([CH2:13][NH:14][C:15]([CH2:16][NH:17][C:18]([c:19]3[c:20]([NH2:29])[cH:21][cH:22][c:23]([C:25]([F:26])([F:27])[F:28])[cH:24]3)=[O:30])=[O:31])[CH2:11][CH2:12]2)[cH:32][cH:33]1.[OH-:34].[OH-:35].[Pd+2:36]>>[NH:7]1[CH2:8][CH2:9][CH:10]([CH2:13][NH:14][C:15]([CH2:16][NH:17][C:18]([c:19]2[c:20]([NH2:29])[cH:21][cH:22][c:23]([C:25]([F:26])([F:27])[F:28])[cH:24]2)=[O:30])=[O:31])[CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 9934977N-(2-((1-(4-chlorobenzyl)piperidin-4-yl)methylamino)-2-oxoethyl)-2-amino-5-(trifluoromethyl)benzamide

Product 1

HCID 184262274-[[N-(2-amino-5-trifluoromethylbenzoyl)glycyl]aminomethyl]piperidine

Sources & evidence

ORD record
ord-e47dfbb84ecc4415852afe5f70aafbc3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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