Dimethyl Sulfoxide → 7-Bromo-4-(4-methoxybenzyl)-1,3,4,5-tetrahydropyrido[2,3-e][1,4]diazepin-2-one

HRID 825376Notes

Reaction equation

HRID 825376 reaction equation
[CH2:1]([O:3][C:4](=[O:2])[CH2:5][N:6]([CH2:7][c:8]1[cH:9][cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]1)[CH2:16][c:17]1[c:18]([NH2:24])[n:19][cH:20][c:21]([Br:23])[cH:22]1)[CH3:25].[CH3:28][S:29]([CH3:30])=[O:31].[H-:27].[Na+:26].[OH2:32]>>[O:3]=[C:4]1[CH2:5][N:6]([CH2:7][c:8]2[cH:9][cH:10][c:11]([O:14][CH3:15])[cH:12][cH:13]2)[CH2:16][c:17]2[c:18]([n:19][cH:20][c:21]([Br:23])[cH:22]2)[NH:24]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ionHCID 962WaterHCID 166653HydrideHCID 59456962[(2-Amino-5-bromo-pyridin-3-ylmethyl)-(4-methoxy-benzyl)amino]acetic acid ethyl ester

Product 1

HCID 594569197-Bromo-4-(4-methoxybenzyl)-1,3,4,5-tetrahydropyrido[2,3-e][1,4]diazepin-2-one

Sources & evidence

ORD record
ord-202867c920ed42efaff895dc6cdae578
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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