HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 82561Generated: October 26, 2026
Cesium carbonate → 1-ethyl-3-[1-(1,3-thiazol-2-yl)-1H-indol-5-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one
https://huagongshe.com/reaction/82561
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Chlorothiazole | HCID 76429 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-(2,3-dihydro-1H-indol-5-yl)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one | HCID 58577282 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-ethyl-3-[1-(1,3-thiazol-2-yl)-1H-indol-5-yl]-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one | HCID 58577309 | 27.9% |
Reaction Steps
A mixture of 3-(2,3-dihydro-1H-indol-5-yl)-1-ethyl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-one (75 mg), 2-chlorothiazole (48.0 mg) and Cs2CO3 (174 mg) in DMF (3 mL) was stirred at 100° C. for 3 days, treated with saturated NaHCO3 solution, and extracted with AcOEt. The organic layer was separated, dried over MgSO4 and concentrated in vacuo. The residue was purified by prep. HPLC and crystallized from AcOEt/Hexane to give the title compound as white crystals (27.0 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08846713B2 |
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| Source dataset | uspto-grants-2014_09 |
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| ORD ID | ord-a616ade2b40049af96929bb3f057c80d |
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| Source note | uspto-grants-2014_09 |
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