Toluene → [2-(2-Dimethylamino-ethyl)-benzo[b]thiophen-3-yl]-thiazol-4-yl-methanol

HRID 826576Notes

Reaction equation

HRID 826576 reaction equation
[Br:1][c:2]1[c:3]2[c:4]([s:5][c:6]1[CH2:7][CH2:8][N:9]([CH3:10])[CH3:11])[cH:12][cH:13][cH:14][cH:15]2.[CH3:16][N:17]([CH3:18])[CH2:19][CH2:20][N:21]([CH3:22])[CH3:23].[CH3:24][CH2:25][CH2:26][CH2:27][Li:28].[CH3:36][c:37]1[cH:38][cH:39][cH:40][cH:41][cH:42]1.[Cl:43][CH2:44][Cl:45].[s:29]1[cH:30][n:31][c:32]([CH:34]=[O:35])[cH:33]1>>[c:2]1([CH:34]([c:32]2[n:31][cH:30][s:29][cH:33]2)[OH:35])[c:3]2[c:4]([s:5][c:6]1[CH2:7][CH2:8][N:9]([CH3:10])[CH3:11])[cH:12][cH:13][cH:14][cH:15]2

Participants

7

Reactant 6

HCID 1140TolueneHCID 6344DichloromethaneHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 2763214Thiazole-4-carboxaldehydeHCID 58591562[2-(3-Bromo-benzo[b]thiophen-2-yl)-ethyl]-dimethyl-amineHCID 178418339Butyllithium

Product 1

HCID 11645411[2-(2-Dimethylamino-ethyl)-benzo[b]thiophen-3-yl]-thiazol-4-yl-methanol

Sources & evidence

ORD record
ord-8fdb53efcde74a59a221fc06607507c4
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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