Acetate → 4-(6-Nitropyridin-3-yl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

HRID 826647Notes

Reaction equation

HRID 826647 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1.[C:11](=[O:12])([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[N:18]1[CH2:19][C:20](=[O:24])[NH:21][CH2:22][CH2:23]1.[C:25](=[O:26])([O-:27])[O-:28].[Cs+:29].[Cs+:30].[O-:38][C:39]([CH3:40])=[O:41].[O-:42][C:43]([CH3:44])=[O:45].[O:31]1[CH2:32][CH2:33][O:34][CH2:35][CH2:36]1.[Pd+2:37]>>[c:2]1([N:21]2[C:20](=[O:24])[CH2:19][N:18]([C:11](=[O:12])[O:13][C:14]([CH3:15])([CH3:16])[CH3:17])[CH2:23][CH2:22]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 8176205-Bromo-2-nitropyridineHCID 3157178Tert-butyl 3-oxopiperazine-1-carboxylate

Product 1

HCID 592909524-(6-Nitropyridin-3-yl)-3-oxopiperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-64f61ca51dc14c3689b3b71b522378a0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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