Sodium Hydroxide → HCID 58577374, compound

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	Methyl 2-{[4-(benzyloxy)phenyl]amino}-4-(trifluoromethyl)pyridine-3-carboxylate	HCID 58577379	—
Solvent	Methanol	HCID 887	—
Product	HCID 58577374	HCID 58577374	89.8%

Reaction Conditions

Temperature	60 °C

Reaction Steps

To a mixture of methyl 2-{[4-(benzyloxy)phenyl]amino}-4-(trifluoromethyl)pyridine-3-carboxylate (255 mg) in MeOH (5 ml) was added 1N NaOH (2.54 mL), and the mixture was stirred at 60° C. for 3 h. After MeOH was evaporated, to the water phase was added 1N HCl (pH=ca. 2). The precipitate was collected by filtration to give the title compound (221 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846713B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-6940c6f1bf4c4ceea722a80d0c973e37
Source note	uspto-grants-2014_09