3-(Trifluoromethyl)aniline → N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-trifluoromethylphenyl)-2,4-pyrimidinediamine

HRID 826793Notes

Reaction equation

HRID 826793 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1.[F:20][C:21]([c:22]1[cH:23][c:24]([NH2:25])[cH:26][cH:27][cH:28]1)([F:29])[F:30]>>[c:2]1([NH:25][c:24]2[cH:23][c:22]([C:21]([F:20])([F:29])[F:30])[cH:28][cH:27][cH:26]2)[n:3][cH:4][c:5]([F:19])[c:6]([NH:8][c:9]2[cH:10][c:11]3[c:12]([cH:13][cH:14]2)[O:15][CH2:16][CH2:17][O:18]3)[n:7]1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 220603622-chloro-5-fluoro-N-(3,4-ethylenedioxyphenyl)-4-pyrimidineamine

Product 1

HCID 22060234N4-(3,4-ethylenedioxyphenyl)-5-fluoro-N2-(3-trifluoromethylphenyl)-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-3d66bd6dfee44bb0b820360139db3421
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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