Carbonate Ion → [2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester

HRID 826807Notes

Reaction equation

HRID 826807 reaction equation
[C:68](=[O:69])([O-:70])[O-:71].[CH2:55]([CH3:56])[O:57][C:58]([CH:59]([CH:60]1[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]1)[Br:66])=[O:67].[Cl:1][c:2]1[cH:3][c:4]([C:36]([OH:37])=[O:38])[cH:5][cH:6][c:7]1[NH:8][C:9](=[O:10])[CH:11]([n:12]1[c:13]2[cH:14][c:15]([F:16])[c:17]([F:18])[cH:19][c:20]2[n:21][c:22]1-[c:23]1[cH:24][n:25][c:26]([Cl:27])[cH:28][cH:29]1)[CH:30]1[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1.[Cl:39][c:40]1[cH:41][cH:42][c:43](-[c:46]2[n:47][c:48]3[c:49]([nH:50]2)[cH:51][cH:52][cH:53][cH:54]3)[cH:44][cH:45]1.[Cs+:72].[Cs+:73]>>[Cl:39][c:40]1[cH:41][cH:42][c:43](-[c:46]2[n:47][c:48]3[c:49]([n:50]2[CH:59]([C:58]([O:57][CH2:55][CH3:56])=[O:67])[CH:60]2[CH2:61][CH2:62][CH2:63][CH2:64][CH2:65]2)[cH:51][cH:52][cH:53][cH:54]3)[cH:44][cH:45]1

Participants

6

Reactant 5

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 7594172-(4-Chlorophenyl)benzimidazoleHCID 2762757Ethyl 2-bromo-2-cyclohexylacetateHCID 441976913-Chloro-4-{2-[2-(6-chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-yl]-2-cyclohexyl-acetylamino}-benzoic acid

Product 1

HCID 66619211[2-(4-Chloro-phenyl)-benzoimidazol-1-yl]-cyclohexyl-acetic acid ethyl ester

Sources & evidence

ORD record
ord-2e4294ca082845d2891c133300d00cc8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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