2,6-Dimethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine → 2-[4-[4-[[7-(2,6-Dimethoxy-3-pyridinyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide

HRID 827102Notes

Reaction equation

HRID 827102 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([NH:11][c:12]3[cH:13][cH:14][c:15]([CH:18]4[CH2:19][CH2:20][N:21]([CH2:24][C:25](=[O:26])[NH2:27])[CH2:22][CH2:23]4)[cH:16][cH:17]3)[n:9][n:10]12.[CH3:28][O:29][c:30]1[n:31][c:32]([O:45][CH3:46])[cH:33][cH:34][c:35]1[B:36]1[O:37][C:38]([CH3:39])([CH3:40])[C:41]([CH3:42])([CH3:43])[O:44]1>>[c:2]1(-[c:35]2[c:30]([O:29][CH3:28])[n:31][c:32]([O:45][CH3:46])[cH:33][cH:34]2)[cH:3][cH:4][c:5]2[cH:6][n:7][c:8]([NH:11][c:12]3[cH:13][cH:14][c:15]([CH:18]4[CH2:19][CH2:20][N:21]([CH2:24][C:25](=[O:26])[NH2:27])[CH2:22][CH2:23]4)[cH:16][cH:17]3)[n:9][n:10]12

Participants

3

Reactant 2

HCID 27584872,6-Dimethoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 667107962-{4-[4-(7-Bromo-pyrrolo[2,1-f][1,2,4]triazin-2-ylamino)-phenyl]-piperidin-1-yl}-acetamide

Product 1

HCID 667108872-[4-[4-[[7-(2,6-Dimethoxy-3-pyridinyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl]amino]phenyl]piperidin-1-yl]acetamide

Sources & evidence

ORD record
ord-384807b7cc71484fbc0deec842880d83
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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