7-Bromo-5-fluoroindolin-2-one → 2-[(7-bromo-5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one

HRID 827149Notes

Reaction equation

HRID 827149 reaction equation
[Br:24][c:25]1[cH:26][c:27]([F:35])[cH:28][c:29]2[c:33]1[NH:32][C:31](=[O:34])[CH2:30]2.[OH:1][CH:2]([CH2:3][N:4]1[C:5](=[O:16])[c:6]2[c:7]([nH:10][c:11]([CH:14]=[O:15])[c:12]2[CH3:13])[CH2:8][CH2:9]1)[CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1>>[OH:1][CH:2]([CH2:3][N:4]1[C:5](=[O:16])[c:6]2[c:7]([nH:10][c:11]([CH:14]=[C:30]3[c:29]4[cH:28][c:27]([F:35])[cH:26][c:25]([Br:24])[c:33]4[NH:32][C:31]3=[O:34])[c:12]2[CH3:13])[CH2:8][CH2:9]1)[CH2:17][N:18]1[CH2:19][CH2:20][O:21][CH2:22][CH2:23]1

Participants

3

Reactant 2

HCID 534188887-Bromo-5-fluoroindolin-2-oneHCID 593759885-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-4-oxo-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carbaldehyde

Product 1

HCID 675310112-[(7-bromo-5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-5-(2-hydroxy-3-morpholin-4-ylpropyl)-3-methyl-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4-one

Sources & evidence

ORD record
ord-eff0ea3e5915470580d9ec5805b730f7
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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