反应详情

A solution of 2-pyridin-2-yl-3-quinolin-4-yl-pyrazolo[1,5-a]piperidin-7-ol (0.04 g, 0.12 mmol) and acetic anhydride (0.2 mL) in pyridine (2 mL) at room temperature is stirred for 24 h. The mixture is partitioned between ethyl acetate and water. The organic portion is washed with water and brine, dried (sodium sulfate), filtered, and concentrated in vacuo. The residue is chromatographed on SiO2 (5% methanol/dichloromethane) to yield the title compound, 0.41 g (91%), as a white solid.

1. customThe mixture is partitioned between ethyl acetate and water
2. washThe organic portion is washed with water and brine
3. dry with materialdried (sodium sulfate)
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe residue is chromatographed on SiO2 (5% methanol/dichloromethane)