N2-Isopropylquinoline-2,6-diamine → 3-[2-chloro-4-(trifluoromethyl)phenyl]-N-[2-(propan-2-ylamino)quinolin-6-yl]prop-2-ynamide
Reaction equation
[CH:17]([CH3:18])([CH3:19])[NH:20][c:21]1[n:22][c:23]2[cH:24][cH:25][c:26]([NH2:31])[cH:27][c:28]2[cH:29][cH:30]1.[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:15])[OH:16])[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1>>[Cl:1][c:2]1[c:3]([C:12]#[C:13][C:14](=[O:16])[NH:31][c:26]2[cH:25][cH:24][c:23]3[n:22][c:21]([NH:20][CH:17]([CH3:18])[CH3:19])[cH:30][cH:29][c:28]3[cH:27]2)[cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-536dfdcc4caa42b4951e347d3e9df7fc
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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