Tert-butyl 4-hydroxypiperidine-1-carboxylate → 4-(5-Nitro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH2:23][CH2:24][CH:25]([OH:28])[CH2:26][CH2:27]1.[C:29]([O:30][C:31]([N:32]1[CH2:33][CH2:34][CH:35]([O:36][c:37]2[cH:38][c:39]3[c:40]([cH:41][cH:42]2)[cH:43][n:44][cH:45][cH:46]3)[CH2:47][CH2:48]1)=[O:49])([CH3:50])([CH3:51])[CH3:52].[F:1][c:2]1[c:3]([N+:12](=[O:13])[O-:14])[c:4]2[cH:5][cH:6][n:7][cH:8][c:9]2[cH:10][cH:11]1>>[c:2]1([O:28][CH:25]2[CH2:24][CH2:23][N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:27][CH2:26]2)[c:3]([N+:12](=[O:13])[O-:14])[c:4]2[cH:5][cH:6][n:7][cH:8][c:9]2[cH:10][cH:11]1Participants
4
Sources & evidence
- ORD record
- ord-793bf5a76b034669a1c2c831026ff41e
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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