反应详情

温度

80 °C

To a stirred solution of 4,7-dioxo-7-phenyl-heptanoic acid (3.57 mmol, 1.0 eq.) in acetic acid (10 ml) was added tert-butyl 4-aminobenzoate (1.05 eq., 3.75 mmol). The mixture was heated to 80° C. for 36 hours. The solvent was evaporated in vacuo and the crude residue purified by flash silica-gel chromatography. Gradient elution with ethyl acetate/hexane (0% to 50% ethyl acetate in hexane over 20 minutes) gave the semi-pure product after combination of the appropriate fractions and evaporation of the solvent in vacuo. The tan solid obtained was used without further purification, 59% yield.

1. customThe solvent was evaporated in vacuo
2. customthe crude residue purified by flash silica-gel chromatography
3. washGradient elution with ethyl acetate/hexane (0% to 50% ethyl acetate in hexane over 20 minutes)
4. customgave the semi-pure product
5. customafter combination of the appropriate fractions and evaporation of the solvent in vacuo
6. customThe tan solid obtained
7. customwas used without further purification, 59% yield