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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 82770Generated: October 30, 2026

Ammonia → tert-butyl (2S,4R)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate

https://huagongshe.com/reaction/82770

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
Reactant(4S)-1-tert-Butoxycarbonyl-4-fluoro-L-prolineHCID 2756017—
Producttert-butyl (2S,4R)-4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 67092752—

Reaction Steps

The title compound was prepared as described in Example 53A substituting (2S,4R)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid for (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid. MS (DCI/NH3) m/z 220 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846730B2
Source datasetuspto-grants-2014_09
ORD IDord-7f3bc86191574f4e9bab7596a51946d1
Source noteuspto-grants-2014_09