Bicarbonate Ion → 2-acetaminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine

HRID 827831Notes

Reaction equation

HRID 827831 reaction equation
[C:29](=[O:30])([OH:31])[O-:32].[CH2:34]([Cl:35])[Cl:36].[CH3:1][C:2]([O:3][C:5]([CH3:6])=[O:7])=[O:4].[NH2:8][CH2:9][CH:10]1[NH:11][c:12]2[c:13]([cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[C:14]([c:17]2[c:18]([F:23])[cH:19][cH:20][cH:21][cH:22]2)=[N:15][CH2:16]1.[Na+:33]>>[C:5]([CH3:6])(=[O:7])[NH:8][CH2:9][CH:10]1[NH:11][c:12]2[c:13]([cH:24][c:25]([Cl:28])[cH:26][cH:27]2)[C:14]([c:17]2[c:18]([F:23])[cH:19][cH:20][cH:21][cH:22]2)=[N:15][CH2:16]1

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 7918Acetic AnhydrideHCID 155632447-Chloro-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine-2-methanamine

Product 1

HCID 155632472-acetaminomethyl-7-chloro-2,3-dihydro-5-(2-fluorophenyl)-1H-1,4-benzodiazepine

Sources & evidence

ORD record
ord-288c15123afb473eb731d7283bb0983c
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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