Formic Acid → 1-(1-Formyl-4-piperidinyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

HRID 828106Notes

Reaction equation

HRID 828106 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[cH:15][n:16][c:17](-[c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[c:18]2-[c:19]2[cH:20][cH:21][n:22][cH:23][cH:24]2)[CH2:12][CH2:13]1.[CH3:32][OH:33].[CH:34](=[O:35])[OH:36].[Pd:37]>>[CH:1]([N:8]1[CH2:9][CH2:10][CH:11]([n:14]2[cH:15][n:16][c:17](-[c:25]3[cH:26][cH:27][c:28]([F:31])[cH:29][cH:30]3)[c:18]2-[c:19]2[cH:20][cH:21][n:22][cH:23][cH:24]2)[CH2:12][CH2:13]1)=[O:35]

Participants

5

Reactant 4

HCID 284Formic AcidHCID 887MethanolHCID 23938PalladiumHCID 113504541-(1-Benzylpiperidin-4-yl)-4-(4-fluorophenyl)-5-(4-pyridyl)imidazole

Product 1

HCID 224641231-(1-Formyl-4-piperidinyl)-4-(4-fluorophenyl)-5-(4-pyridinyl)imidazole

Sources & evidence

ORD record
ord-8b00b18ffadc4830b5c2460a79263b39
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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