Ethanol → (1RS,2RS)-1-(4-fluorophenyl)-1-hydroxy-3-(4-(trifluoromethyl)phenyl)-2-propylamine

HRID 828133Notes

Reaction equation

HRID 828133 reaction equation
[CH3:27][CH2:28][OH:29].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:14][c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[NH:10][C:11](=[O:13])[O:12]2)[cH:6][cH:7]1.[Na+:26].[OH-:25].[OH2:30]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH:9]([NH2:10])[CH2:14][c:15]2[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]2)[OH:12])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 22262143(4RS,5RS)-5-(4-fluorophenyl)-4-((4-(trifluoromethyl)phenyl)methyl)-1,3-oxazolidin-2-one

Product 1

HCID 22261479(1RS,2RS)-1-(4-fluorophenyl)-1-hydroxy-3-(4-(trifluoromethyl)phenyl)-2-propylamine

Sources & evidence

ORD record
ord-88a8c6469ff84183a9aba083c3fa8ab0
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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