Bicarbonate Ion → 2-(4-Ethoxycarbonyl-1-piperazinyl)-3,6-difluoro-5-nitrobenzyl chloride

HRID 828312Notes

Reaction equation

HRID 828312 reaction equation
[C:30](=[O:31])([O-:32])[OH:33].[CH:35]([Cl:36])([Cl:37])[Cl:38].[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][OH:6])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1.[Na+:34].[OH2:29].[S:25]([Cl:26])([Cl:27])=[O:28]>>[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][Cl:27])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1

Participants

7

Reactant 6

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 6212ChloroformHCID 24386Thionyl ChlorideHCID 156225283,6-Difluoro-2-(4-ethoxycarbonyl-1-piperazinyl)-5-nitrobenzyl alcohol

Product 1

HCID 156318302-(4-Ethoxycarbonyl-1-piperazinyl)-3,6-difluoro-5-nitrobenzyl chloride

Sources & evidence

ORD record
ord-fede001bcde94f52873e3502b43bdac9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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