Potassium Cation → 2-chloro-5-(1-methyl-1H-pyrazol-4-yl)nicotinonitrile

HRID 828548Notes

Reaction equation

HRID 828548 reaction equation
[Br:16][c:17]1[cH:18][n:19][c:20]([Cl:25])[c:21]([C:22]#[N:23])[cH:24]1.[C:26](=[O:27])([O-:28])[O-:29].[CH2:32]1[O:33][CH2:34][CH2:35][O:36][CH2:37]1.[CH3:1][n:2]1[n:3][cH:4][c:5]([B:7]2[O:8][C:9]([CH3:10])([CH3:11])[C:12]([CH3:13])([CH3:14])[O:15]2)[cH:6]1.[K+:30].[K+:31].[OH2:38]>>[CH3:1][n:2]1[n:3][cH:4][c:5](-[c:17]2[cH:18][n:19][c:20]([Cl:25])[c:21]([C:22]#[N:23])[cH:24]2)[cH:6]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 27739871-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazoleHCID 219482695-Bromo-2-chloronicotinonitrile

Product 1

HCID 580154822-chloro-5-(1-methyl-1H-pyrazol-4-yl)nicotinonitrile

Sources & evidence

ORD record
ord-0fae82db681c4115a06d70e082b0cbbf
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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