反应详情

cis-N-(2-{[7-Amino-8-(2-fluorobenzyl)-5,6,7,8-tetrahydronaphthalen-2-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide (60 mg, 0.105 mmol) in acetyl chloride (2 mL, 28.1 mmol) was heated under reflux for 30 min. The acetyl chloride was evaporated in vacuo. The crude product dissolved in dichloromethane and washed successively with saturated sodium bicarbonate and saturated sodium chloride and dried (magnesium sulfate). The crude product was used for next step without further purification. Yield: 38 mg (colorless foam).

1. temperatureunder reflux for 30 min
2. customThe acetyl chloride was evaporated in vacuo
3. dissolutionThe crude product dissolved in dichloromethane
4. washwashed successively with saturated sodium bicarbonate and saturated sodium chloride
5. dry with materialdried (magnesium sulfate)
6. customThe crude product was used for next step without further purification