Carbonate Ion → 6-Chloro-4-(5-cyclobutylaminomethyl-pyrazin-2-ylamino)-2-methyl-2H-pyridazin-3-one

HRID 828663Notes

Reaction equation

HRID 828663 reaction equation
[Br:14][c:15]1[c:16](=[O:23])[n:17]([CH3:22])[n:18][c:19]([Cl:21])[cH:20]1.[C:24](=[O:25])([O-:26])[O-:27].[CH:1]1([NH:5][CH2:6][c:7]2[n:8][cH:9][c:10]([NH2:13])[n:11][cH:12]2)[CH2:2][CH2:3][CH2:4]1.[Cs+:28].[Cs+:29].[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1>>[CH:1]1([NH:5][CH2:6][c:7]2[n:8][cH:9][c:10]([NH:13][c:15]3[c:16](=[O:23])[n:17]([CH3:22])[n:18][c:19]([Cl:21])[cH:20]3)[n:11][cH:12]2)[CH2:2][CH2:3][CH2:4]1

Participants

6

Reactant 5

HCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 592164744-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-oneHCID 667422585-Cyclobutylaminomethyl-pyrazin-2-ylamine

Product 1

HCID 667421676-Chloro-4-(5-cyclobutylaminomethyl-pyrazin-2-ylamino)-2-methyl-2H-pyridazin-3-one

Sources & evidence

ORD record
ord-73e8b58b24734cc6b6879b2d6ec9b055
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…